Large swathe of Universal Studios backlot torched
1. "Fire... BAD!" Universal is the original home of Frankenstein... and his many stunt doubles -- now seriously spooked, loose, and on the march. 2. The fire destroyed the Courthouse set from "Back to the Future," thus leaving all possible time-travel knowledge in the "hands" of SkyNet.
Combined army of Frankensteins, Terminators is insurmountable, incomprehensible. Thousands of linguists are killed (not that they were making much of a living anyway).
Humanity's last hope for quelling these tormentors comes from an unexpected place: The Rise of the Bridezillas.